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Partial Thromboplastin Time (PTT), Activated
Partial Thromboplastin Time (PTT), Activated
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The aPTT is sensitive to deficiency or inhibition of factors in the intrinsic pathway. These include the contact factors; high molecular weight kininogen (HMWK), prekallikrein, and factor XII along with procoagulant factors XI, IX, VIII. The aPTT is less sensitive to deficiencies of X, V, prothrombin, and fibrinogen.1 Nonspecific, lupus-type anticoagulants can also extend the aPTT, but the more sensitive aPTT-LA test should be used to screen for this condition.
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