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Prostate-specific Antigen (PSA), Complexed
Prostate-specific Antigen (PSA), Complexed
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PSA is a single-chain glycoprotein typically found in the cytoplasm of the epithelial cells lining the acini and ducts of the prostate gland. PSA is a neutral serine protease of 240 amino acids involved in the lysis of seminal coagulum. PSA is present in the serum of males with normal, benign hyperplastic, and malignant prostate tissue. PSA exists predominantly in circulation in complexes with various protease inhibitors. The most prevalent form of complexed cPSA that can be detected is bound to α1-antichymotrypsin.
cPSA can be useful for determining residual disease and early recurrence after therapy when used in conjunction with other diagnostic indices. cPSA levels increase in men with cancer of the prostate, and after prostatectomy, cPSA levels routinely fall to a very low level.
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