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Cortisol, Urinary Free
Cortisol, Urinary Free
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The diagnosis of Cushing syndrome (CS) requires evidence of cortisol hypersecretion. While serum cortisol levels fluctuate unpredictably and are strongly dependent on concurrent cortisol-binding globulin (CBG) levels, a 24-hour urine specimen integrates the cortisol production for an entire day and is not affected by CBG. Urinary cortisol reflects the portion of serum-free cortisol filtered by the kidney, and correlates well with cortisol secretion rate.
The most common causes of CS are pituitary adenoma (65% to 70%), adrenal tumor (15% to 20%), and ectopic CS (10% to 15%).
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How Do I Get My Lab?
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